"FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity."
Mahon P.C. , Hirota K. , Semenza G.L.
Genes Dev.15:2675-2686(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , Yamamoto J. , Saito K. , Kawai Y. , Isono Y. , Nakamura Y. , Nagahari K. , Murakami K. , Yasuda T. , Iwayanagi T. , Wagatsuma M. , Shiratori A. , Sudo H. , Hosoiri T. , Kaku Y. , Kodaira H. , Kondo H. , Sugawara M. , Takahashi M. , Kanda K. , Yokoi T. , Furuya T. , Kikkawa E. , Omura Y. , Abe K. , Kamihara K. , Katsuta N. , Sato K. , Tanikawa M. , Yamazaki M. , Ninomiya K. , Ishibashi T. , Yamashita H. , Murakawa K. , Fujimori K. , Tanai H. , Kimata M. , Watanabe M. , Hiraoka S. , Chiba Y. , Ishida S. , Ono Y. , Takiguchi S. , Watanabe S. , Yosida M. , Hotuta T. , Kusano J. , Kanehori K. , Takahashi-Fujii A. , Hara H. , Tanase T.-O. , Nomura Y. , Togiya S. , Komai F. , Hara R. , Takeuchi K. , Arita M. , Imose N. , Musashino K. , Yuuki H. , Oshima A. , Sasaki N. , Aotsuka S. , Yoshikawa Y. , Matsunawa H. , Ichihara T. , Shiohata N. , Sano S. , Moriya S. , Momiyama H. , Satoh N. , Takami S. , Terashima Y. , Suzuki O. , Nakagawa S. , Senoh A. , Mizoguchi H. , Goto Y. , Shimizu F. , Wakebe H. , Hishigaki H. , Watanabe T. , Sugiyama A. , Takemoto M. , Kawakami B. , Yamazaki M. , Watanabe K. , Kumagai A. , Itakura S. , Fukuzumi Y. , Fujimori Y. , Komiyama M. , Tashiro H. , Tanigami A. , Fujiwara T. , Ono T. , Yamada K. , Fujii Y. , Ozaki K. , Hirao M. , Ohmori Y. , Kawabata A. , Hikiji T. , Kobatake N. , Inagaki H. , Ikema Y. , Okamoto S. , Okitani R. , Kawakami T. , Noguchi S. , Itoh T. , Shigeta K. , Senba T. , Matsumura K. , Nakajima Y. , Mizuno T. , Morinaga M. , Sasaki M. , Togashi T. , Oyama M. , Hata H. , Watanabe M. , Komatsu T. , Mizushima-Sugano J. , Satoh T. , Shirai Y. , Takahashi Y. , Nakagawa K. , Okumura K. , Nagase T. , Nomura N. , Kikuchi H. , Masuho Y. , Yamashita R. , Nakai K. , Yada T. , Nakamura Y. , Ohara O. , Isogai T. , Sugano S. more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , Bird C.P. , Ainscough R. , Almeida J.P. , Ashwell R.I.S. , Ambrose K.D. , Babbage A.K. , Bagguley C.L. , Bailey J. , Banerjee R. , Bates K. , Beasley H. , Bray-Allen S. , Brown A.J. , Brown J.Y. , Burford D.C. , Burrill W. , Burton J. , Cahill P. , Camire D. , Carter N.P. , Chapman J.C. , Clark S.Y. , Clarke G. , Clee C.M. , Clegg S. , Corby N. , Coulson A. , Dhami P. , Dutta I. , Dunn M. , Faulkner L. , Frankish A. , Frankland J.A. , Garner P. , Garnett J. , Gribble S. , Griffiths C. , Grocock R. , Gustafson E. , Hammond S. , Harley J.L. , Hart E. , Heath P.D. , Ho T.P. , Hopkins B. , Horne J. , Howden P.J. , Huckle E. , Hynds C. , Johnson C. , Johnson D. , Kana A. , Kay M. , Kimberley A.M. , Kershaw J.K. , Kokkinaki M. , Laird G.K. , Lawlor S. , Lee H.M. , Leongamornlert D.A. , Laird G. , Lloyd C. , Lloyd D.M. , Loveland J. , Lovell J. , McLaren S. , McLay K.E. , McMurray A. , Mashreghi-Mohammadi M. , Matthews L. , Milne S. , Nickerson T. , Nguyen M. , Overton-Larty E. , Palmer S.A. , Pearce A.V. , Peck A.I. , Pelan S. , Phillimore B. , Porter K. , Rice C.M. , Rogosin A. , Ross M.T. , Sarafidou T. , Sehra H.K. , Shownkeen R. , Skuce C.D. , Smith M. , Standring L. , Sycamore N. , Tester J. , Thorpe A. , Torcasso W. , Tracey A. , Tromans A. , Tsolas J. , Wall M. , Walsh J. , Wang H. , Weinstock K. , West A.P. , Willey D.L. , Whitehead S.L. , Wilming L. , Wray P.W. , Young L. , Chen Y. , Lovering R.C. , Moschonas N.K. , Siebert R. , Fechtel K. , Bentley D. , Durbin R.M. , Hubbard T. , Doucette-Stamm L. , Beck S. , Smith D.R. , Rogers J. more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , Yooseph S. , Lu F. , Nusskern D.R. , Shue B.C. , Zheng X.H. , Zhong F. , Delcher A.L. , Huson D.H. , Kravitz S.A. , Mouchard L. , Reinert K. , Remington K.A. , Clark A.G. , Waterman M.S. , Eichler E.E. , Adams M.D. , Hunkapiller M.W. , Myers E.W. , Venter J.C. more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , Schupp I. more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor."
Lando D. , Peet D.J. , Gorman J.J. , Whelan D.A. , Whitelaw M.L. , Bruick R.K.
Genes Dev.16:1466-1471(2002) [PubMed] [Europe PMC] [Abstract]

"Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family."
Hewitson K.S. , McNeill L.A. , Riordan M.V. , Tian Y.-M. , Bullock A.N. , Welford R.W. , Elkins J.M. , Oldham N.J. , Bhattacharya S. , Gleadle J.M. , Ratcliffe P.J. , Pugh C.W. , Schofield C.J.
J. Biol. Chem.277:26351-26355(2002) [PubMed] [Europe PMC] [Abstract]

"Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity."
Lancaster D.E. , McNeill L.A. , McDonough M.A. , Aplin R.T. , Hewitson K.S. , Pugh C.W. , Ratcliffe P.J. , Schofield C.J.
Biochem. J.383:429-437(2004) [PubMed] [Europe PMC] [Abstract]

"Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases."
Koivunen P. , Hirsila M. , Gunzler V. , Kivirikko K.I. , Myllyharju J.
J. Biol. Chem.279:9899-9904(2004) [PubMed] [Europe PMC] [Abstract]

"Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor."
Linke S. , Stojkoski C. , Kewley R.J. , Booker G.W. , Whitelaw M.L. , Peet D.J.
J. Biol. Chem.279:14391-14397(2004) [PubMed] [Europe PMC] [Abstract]

"Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)."
Cockman M.E. , Lancaster D.E. , Stolze I.P. , Hewitson K.S. , McDonough M.A. , Coleman M.L. , Coles C.H. , Yu X. , Hay R.T. , Ley S.C. , Pugh C.W. , Oldham N.J. , Masson N. , Schofield C.J. , Ratcliffe P.J.
Proc. Natl. Acad. Sci. U.S.A.103:14767-14772(2006) [PubMed] [Europe PMC] [Abstract]

"Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways."
Zheng X. , Linke S. , Dias J.M. , Zheng X. , Gradin K. , Wallis T.P. , Hamilton B.R. , Gustafsson M. , Ruas J.L. , Wilkins S. , Bilton R.L. , Brismar K. , Whitelaw M.L. , Pereira T. , Gorman J.J. , Ericson J. , Peet D.J. , Lendahl U. , Poellinger L. more...
Proc. Natl. Acad. Sci. U.S.A.105:3368-3373(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)."
Webb J.D. , Muranyi A. , Pugh C.W. , Ratcliffe P.J. , Coleman M.L.
Biochem. J.420:327-333(2009) [PubMed] [Europe PMC] [Abstract]

"Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1."
Sakamoto T. , Seiki M.
J. Biol. Chem.284:30350-30359(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes."
Martinez-Noel G. , Galligan J.T. , Sowa M.E. , Arndt V. , Overton T.M. , Harper J.W. , Howley P.M.
Mol. Cell. Biol.32:3095-3106(2012) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway."
Dann C.E. III , Bruick R.K. , Deisenhofer J.
Proc. Natl. Acad. Sci. U.S.A.99:15351-15356(2002) [PubMed] [Europe PMC] [Abstract]

"Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha."
Elkins J.M. , Hewitson K.S. , McNeill L.A. , Seibel J.F. , Schlemminger I. , Pugh C.W. , Ratcliffe P.J. , Schofield C.J.
J. Biol. Chem.278:1802-1806(2003) [PubMed] [Europe PMC] [Abstract]

"Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau."
Lee C. , Kim S.J. , Jeong D.G. , Lee S.M. , Ryu S.E.
J. Biol. Chem.278:7558-7563(2003) [PubMed] [Europe PMC] [Abstract]

"Selective inhibition of factor inhibiting hypoxia-inducible factor."
McDonough M.A. , McNeill L.A. , Tilliet M. , Papamicael C.A. , Chen Q.Y. , Banerji B. , Hewitson K.S. , Schofield C.J.
J. Am. Chem. Soc.127:7680-7681(2005) [PubMed] [Europe PMC] [Abstract]

"Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates."
Hewitson K.S. , Lienard B.M. , McDonough M.A. , Clifton I.J. , Butler D. , Soares A.S. , Oldham N.J. , McNeill L.A. , Schofield C.J.
J. Biol. Chem.282:3293-3301(2007) [PubMed] [Europe PMC] [Abstract]

"Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor."
Coleman M.L. , McDonough M.A. , Hewitson K.S. , Coles C. , Mecinovic J. , Edelmann M. , Cook K.M. , Cockman M.E. , Lancaster D.E. , Kessler B.M. , Oldham N.J. , Ratcliffe P.J. , Schofield C.J.
J. Biol. Chem.282:24027-24038(2007) [PubMed] [Europe PMC] [Abstract]

"Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH)."
Hewitson K.S. , Holmes S.L. , Ehrismann D. , Hardy A.P. , Chowdhury R. , Schofield C.J. , McDonough M.A.
J. Biol. Chem.283:25971-25978(2008) [PubMed] [Europe PMC] [Abstract]

"Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor."
Conejo-Garcia A. , McDonough M.A. , Loenarz C. , McNeill L.A. , Hewitson K.S. , Ge W. , Lienard B.M. , Schofield C.J. , Clifton I.J.
Bioorg. Med. Chem. Lett.20:6125-6128(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of human FIH-1 in complex with quinol family inhibitors."
Moon H. , Han S. , Park H. , Choe J.
Mol. Cells29:471-474(2010) [PubMed] [Europe PMC] [Abstract]

"The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases."
Chowdhury R. , Yeoh K.K. , Tian Y.M. , Hillringhaus L. , Bagg E.A. , Rose N.R. , Leung I.K. , Li X.S. , Woon E.C. , Yang M. , McDonough M.A. , King O.N. , Clifton I.J. , Klose R.J. , Claridge T.D. , Ratcliffe P.J. , Schofield C.J. , Kawamura A.
EMBO Rep.12:463-469(2011) [PubMed] [Europe PMC] [Abstract]

"Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains."
Yang M. , Chowdhury R. , Ge W. , Hamed R.B. , McDonough M.A. , Claridge T.D. , Kessler B.M. , Cockman M.E. , Ratcliffe P.J. , Schofield C.J.
FEBS J.278:1086-1097(2011) [PubMed] [Europe PMC] [Abstract]

"Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor."
Yang M. , Ge W. , Chowdhury R. , Claridge T.D. , Kramer H.B. , Schmierer B. , McDonough M.A. , Gong L. , Kessler B.M. , Ratcliffe P.J. , Coleman M.L. , Schofield C.J.
J. Biol. Chem.286:7648-7660(2011) [PubMed] [Europe PMC] [Abstract]